E-Books →Rejuvenation and Longevity Introduction to Rejuvenology

Free Download Rejuvenation and Longevity: Introduction to Rejuvenology by Khachik K. Muradian, Vadim E. Fraifeld
English | September 4, 2024 | ISBN: 303164994X | 138 pages | MOBI | 1.26 Mb
This book is a systematic collection and critical analysis of current information on rejuvenation, starting from the evolutionary aspects of the origin of life, immortality, and aging. Models, mechanisms, and types of rejuvenation are the key subjects of the book. Processes like cellular reprogramming, resetting of the aging clock, immortal unicellulars and cell cultures are explored through the lens of rejuvenation. Recent discoveries in this field offer a nuanced view of rejuvenation that has fascinated mankind since early history.
There is evidence, though still controversial, indicating that biological time could be reversible. Indeed, under specific experimental conditions, cells can be moved back and forth along the age axis. Differentiation status and replicative age of cells can be modified not only by defined transcription factors, but also by 'cocktails' of small molecules originating from natural substances or well-known longevity-promoting drugs. Still in its infancy, such findings open up the perspective of in vivo rejuvenation trials. Special attention is given to the quasi-immortal and extremely long-lived multicellular animal species as well as to the role of rejuvenation in treatment of pathology and healthy aging.